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In MS, aberrant FOCM is linked with disease onset, cognitive impairments, demyelination, and neurodegeneration [51, 216]

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However, mathematical modeling suggests that MCT inhibition alone may not significantly decrease lactate production due to autoregulatory feedback on flux control [213]

Overall, pFeSAN possesses a higher degree of graphitization and abundant nitrogen defect, indicating that the designed biomimetic synthetic strategy enables the effective modulation of the local electronic structure of Fe in pFeSAN and thereby affect their enzyme-like activity

In addition, the prolonged retention of drugs in the lungs because of impaired clearance mechanisms can reduce the intended effects of the treatment and increase the risk of side effects