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The role of JNK as an amplification pathway for mitochondrial damage induced by APAP has been extensively investigated using different approaches, from pharmacological inhibition to antisense oligonucleotides-mediated knockdown of Jnk1 and Jnk2 or global Jnk2 deletion in mice (Xie et al., 2015), highlighting the hierarchical relationship between ASK1 and JNK in APAP hepatotoxicity

[DOI] [PubMed] [Google Scholar] 109.Katt M.E., Mayo L.N., Ellis S.E., Mahairaki V., Rothstein J.D., Cheng L., Searson P.C

T.QustiS

Cereb Cortex 27:718730

Zhang G, Luk BT, Wei X, Campbell GR, Fang RH, Zhang L, et al

Treatment with methionine was stopped, betaine was continued with 250 mg/kg PO and folic acid with 10 mg PO per day
