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The honest summary is thinner than that list makes it sound, because no long-term human safety study has been run

A study in 49 people with knee osteoarthritis found that taking 3.4 grams of MSM per day for 12 weeks reduced pain and stiffness and improved physical function, compared to a placebo ( Additionally, it can enhance the effectiveness of other common supplements used to treat arthritis such as glucosamine sulfate, chondroitin sulfate and boswellic acid
Sampson and Mazmanian, 2015

Obese subjects show increased plasma FFA levels, while GH secretion is practically abolished, and if we suppress circulating FFA with antilipolytic drugs, obese patients regain normal GH secretion [110, 111]

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The modifications discussed below pertain specifically to urology and will become effective on January 1, 2024, across all payers