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Yang Xia, Chunye Huang, Min Zhong, and Hongguang Zhong contributed equally to this work

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Peripheral factorsincluding ATPase family AAA domain-containing protein 3 (ATAD3), prohibitin 1/2 (PHB1/2), and mitofusin 1 (MFN1)modulate mitochondrial biogenesis, apoptosis, and mito-nuclear signaling without directly binding to mtDNA [29]

Several of the substances are slated for review by the Pharmacy Compounding Advisory Committee (PCAC), with meetings scheduled as early as July 2026