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Neural Regen Res 19(8):17181727
This was critical, as cats in end stage CKD suffer from uremia, making them susceptible to inflammation and cytokine storms
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Overall, the formation of ADAs neutralizes the activity of therapeutic proteins, altering pharmacokinetics, biodistribution, and can cause hypersensitivity reactions [47], or cross react with endogenous proteins [5]
Immune Suppressive Mechanisms in the Tumor Microenvironment
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