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Data from behavioral studies using scopolamine amnesia and aged rat models, where dihexa was able to reverse cognitive deficits, indicated that the metabolic stability and BBB permeability of dihexa were apparently high enough to attain therapeutic brain levels after oral administration

Dulaglutide Dulaglutide is another GLP- 1 synthetic analog which consists of two DPP- 4 resistant GLP- 1 molecules that are covalently linked to a modified IgG4 Fc fragment that acts as carrier, limiting the renal clearance of the molecule [93]

Free Radic Biol Med 29(11):11221128 Jain SK, McVie R (1999) Hyperketonemia can increase lipid peroxidation and lower glutathione levels in human erythrocytes in vitro and in type 1 diabetic patients

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The MGD to IST mutation was generated by replacing the amino acids of M381, G382, and D383 with I, S, and T, respectively