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Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1

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These effects are mediated by shifts in methylation balance, activation of stress-response pathways, and improved mitochondrial function

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doi: 10.1200/JCO.2017.75.7724 Summary Keywords lymphatic vessels, lymph node metastasis, tumor-draining lymph node (TDLN), immunotherapy, cancer metastasis Citation Lei P-J, Fraser C, Jones D, Ubellacker JM and Padera TP (2024) Lymphatic system regulation of anti-cancer immunity and metastasis