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Furthermore, the administration of denatonium benzoate, in conjunction with gavage of glucose, causes the secretion of GLP-1 and subsequently elevates plasma insulin levels and reduces plasma glucose in db/db mice [195]

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Notably, it has been found that silencing long noncoding RNAs (lncRNAs) nuclear paraspeckle assembly transcript 1 (NEAT1) promotes microRNA-129 and microRNA-204 inhibition of the MAPK/ERK signaling pathway and attenuates FLS synovitis in RA ( In addition to this, it is also important to alleviate the development of RA by down-regulating various cytokines