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Finally, -butyrobetaine dioxygenase (BBD) catalyzes the hydroxylation of BB to produce carnitine [158]

Fumaric acid accumulation also inhibits the activity of adenylosuccinate lyase (ADSL) in the purine de novo synthesis pathway, resulting in an increase in succinylaminoimidazolecarboxamide ribose (SAICAR) and adenosine succinate, which can cause damage to the central nervous system [84]

In a mouse model, low L-lysine diet decreased the concentrations of GA in and brain in a dose-dependent manner, whereas 3-OH-GA concentrations remained virtually unchanged, L-arginine supplementation amplified this biochemical effect and thus further decreased the cerebral and hepatic GA concentrations and 3-OH-GA concentration (23)

An inhibitor of the acetyltransferases CBP/p300 exerts antineoplastic effects on gastrointestinal stromal tumor cells