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For instance, decreased NAD availability can lead to compromised mitochondrial function, resulting in increased oxidative stress and neuronal damage

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However, data obtained from animal models and human subjects suggest that acetaldehyde may play a role in liver damage, especially that associated with ethanol (sections 3.1.1 and 8.10)

Older individuals often have reduced nitric oxide production, stiffer blood vessels, and altered responses to vasoactive compounds

Maintaining a high ratio of GSH to its oxidized form GSSG, utilizing NADPH conversion to NADP, is the principal mechanism for protecting RBCs from ROS generated from the release of oxygen