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Statements Author contributions X-YL collected the related papers and was a major contribution in writing the manuscript

An increase in LDL-C of more than 10 mg/dL without clear dietary explanation requires clinical decision-making

The research rationale for a selective NNMT inhibitor is to interrupt exactly that diversion, so the cell keeps more of its NAD+ pool and can run its mitochondrial machinery again

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Prednisone, like other corticosteroids should not be administered concomitantly with: - Barbiturates, carbamazepine, phenytoin, rifampin or ephedrine: these drugs enhance the metabolism of corticosteroids reducing their therapeutic action