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South Africa get some of di toughest laws against skin lighteners

10.1073/pnas.80.14.4546 29 CassottaM.GeertsH.HarbomL.OuteiroT

Profibrotic signaling is reinforced by Polycomb Repressive Complex 2/Enhancer of Zeste Homolog (PRC2/EZH2)- and G9a-driven methylation (Histone H3 Lysine 27 Trimethylation/Histone H3 Lysine 9 Di/Trimethylation (H3K27me3/H3K9me2/3)) and by p300-dependent acetylation, which together promote TGF- and STAT3 programs in fibrotic organs

Yes, many people find that taking them together is highly beneficial

doi: 10.1016/j.bbamcr.2011.03.001

Collectively, these multidirectional interactions illustrate that PD is not confined to the brain but reflects a broader systemlevel dysregulation