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The fluctuations in tissue oxygen levels initiate a regenerative mechanism and direct the oxygen supply to the tissues where it is most needed

Fundamental research has shown that MNP exposure can lead to ovarian inflammation, oxidative stress, endoplasmic reticulum (ER) stress, and apoptosis, resulting in ovarian atrophy [185,186]

High levels of PHGDH protect GBM cells from hypoxia-induced cell death and starvation by regulating redox homeostasis and the NADPH/NADP+ ratio [29]

[DOI] [PMC free article] [PubMed] [Google Scholar] 109.Madiraju P, Pande SV, Prentki M, Madiraju SR

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