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When administered together, their mechanisms converge to amplify appetite regulation, energy intake reduction, and glycemic improvements, exceeding the individual effects of monotherapy by acting on complementary neuroendocrine circuits regulating body weight and metabolism 1-3
Arch Intern Med 1992;152:20822088

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This distinction is significant because TPH1 expression in the hypothalamus and pineal gland allows for endogenous serotonin production enhancement without the side effect profiles associated with selective serotonin reuptake inhibitors (SSRIs)
