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The safety profile of prolonged ocular use of many plant-derived compounds remains largely unexamined and necessitates thorough investigation

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Natural compounds such as piperlongumine and cotylenin A exhibit synergistic therapeutic efficacy with SAS, which suggest that the triple combined treatment with piperlongumine, piperlongumine and SAS is highly effective against pancreatic cancer (Kasukabe et al., 2016

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