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NLRP3 inflammasome activates caspase-1 to cleaves pro-IL-1 and pro-IL-18 into the active forms IL-1 and IL-18, meanwhile, cleaves the amino-terminal fragment of the key protein gasdermin D (GSDMD) to form N-GSDMD, which oligomerizes and forms membrane pore formation leading to pyroptosis and subsequent inflammatory response

These reactions are responsible for converting androgens (male sex hormones) to estrogens (female sex hormones)

Jeulin C, Soufir JC, Weber P et al (1989) Catalase activity in human spermatozoa and seminal plasma

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Exocytosis of IgG as mediated by the receptor, FcRn: An analysis at the single-molecule level

PLoS One 6:e19603