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These molecules have a strong affinity for the estrogen receptors (ERs) ER, ER, and G-protein coupled ER1 (GPER1), through which, after binding, induce a direct or indirect genomic signaling to change the expression pattern of several genes (Fuentes and Silveyra, 2019)

Joints requiring a large surface area of cartilage restoration are challenging for a number of reasons, including mechanical demands, graft fixation, and the large number of cells required for transplantation (in cell based therapies)

Targeting MTHFD2 to exploit cancer-specific metabolism and the DNA damage response

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10.1186/s12967-023-04842-9 25 HanS.BaoX.ZouY.WangL.LiY.YangL.et al (2023)