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By employing Candida antarctica lipase B (CALB) as the model enzyme with the Ser-His-Asp catalytic triad, a highly active cysteine-lipase having a Cys-His-Asp catalytic triad and additional mutations W104V/A281Y/A282Y/V149G can be evolved, showing a 40-fold higher catalytic efficiency than wild-type CALB in the hydrolysis of 4-nitrophenyl benzoate, and tolerating bulky substrates

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Early treatment of acute hepatitis C infection is cost-effective in HIV-infected men-who-have-sex-with-men

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It has long been recognized that LDL-C underestimates risk of ASCVD in the setting of hypertriglyceridemia (467)

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