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Transfection medium was replaced 6 h post-transfection and transfected cells were analyzed 48 h post-transfection

Long-term inhibition of ODC1 in APP/PS1 mice rescues amyloid pathology and switches astrocytes from a reactive to active state

Hypoxia-inducible factors (HIFs) are critical transcription regulators that respond to hypoxia [165]

Given that KRAS mutations are prevalent in almost 30% of non-small cell lung cancer (NSCLC) patients [2], we chose a Kras G12D -driven spontaneous lung cancer murine model to elucidate the detailed mechanism by which DDX3X regulates lung cancer progression, which might be also extended to KRAS wildtype lung cancers

cerevisiae strain with pTEF1-GSH1 at the GSH1 locus on both alleles, and pGSH1-URA3 at the URA3 locus on both alleles was constructed (strain designated homozygous pGSH1-URA3 in the following context) (Figure S1 B )

Still, careful monitoring of thyroid function and medication requirements remains critical, especially in the context of significant weight loss