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Altayyar M, Nasser JA, Thomopoulos D, Bruneau M, Jr

Start at the lower end, check tolerance, and reassess after 812 weeks

We showed that inherent anxiety at baseline and elevated expression of the mineralocorticoid receptors (MR) in the hippocampus predisposes to a stress-induced suppression of expression of metabotropic glutamate receptors-2 (mGlu2, a key inhibitor of spontaneous glutamate release) with development of depressive-like behavior via epigenetic mechanisms of histone acetylation [20]

[DOI] [PubMed] [Google Scholar] 155.Vaezi Z, Amini A

But we need more large, good-quality studies to be sure

Engel AG, Rebouche CJ, Wilson DM, Glasgow AM, Romsche CA, Cruse RP