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It is yet unclear how PNLDC1 affects other elements of the piRNA processing pathway, despite being the 35 exonuclease in charge of piRNA trimming

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Death from within: how oligodendrocyte intrinsic mechanisms could lead to death during cuprizone treatment Although MS is generally described as an autoimmune and inflammatory disease of the CNS, some argue that MS may initially reflect a non-inflammatory degenerative disorder that affects myelin and in doing so, begins a cascade that elicits the more commonly reported inflammatory response (for review see [8])

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