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Activation of antigen-presenting cells by microbial products breaks self tolerance and induces autoimmune disease

LINC01127, in collaboration with Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4), activates the JNK pathway to enhance the communication with the NF-B pathway, culminating in the augmentation of the migratory capabilities and the self-renewal rate of glioma stem cells (GSCs) [151]

In the study, various flavonoidsflavonols, flavanones, flavones, anthocyanidins, hydroxycinnamates, and flavanolswere studied

(accessed May 2022)

This combination also improved the two-year survival rate from 10.4% to 26.5%, leading to its adoption as the Stupp protocol