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Vitamin B12 is very safe, however if you do have an excessive amount it can lead to side effects Here at The Nurse Clinic we administer B12 Injections for Dietary or Wellbeing purposes unless you have evidence from your GP showing diagnosis of a medical condition which can lead to B12 deficiency The recommended guidelines for the administration of vitamin B12 injections can be found below however generally it is suggested that the following is advised: For Dietary or Wellness Every 6 months For B12 Deficiency Every 2-3 months INTRAMUSCULAR (IM) will be released into the systemic circulation reasonably quickly, bypassing the gastric system therefore you will absorb much more