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An imbalance in the apoptosis rate and the accumulation of cellular debris lead to SLE

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Eid et al., 2012), the interictal elevated glutamate may largely reflect higher cellular glutamate levels within astrocytes, probably due to chronic impaired glutamine synthetase function and perhaps also impaired oxidation, since neuronal number and volume is reduced much more than total tissue glutamate levels (D

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Several investigators have identified the corresponding cDNA, and the gene has been localized to chromosome 22