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Park SY, Lee HJ, Ji SM, Kim ME, Jigden B, Lim JE, et al

Torre et al., 2018)

Its primary mechanism involves upregulating VEGF (vascular endothelial growth factor), which promotes new blood vessel growth at the site of damage

10.1182/blood.2024026916 135 WangL.LuoJ.ChenG.FangM.WeiX.LiY.et al (2020)

This release-of-autoinhibition model for IGF1R activation is supported by a crystal structure of the IGF1R ectodomain in complex with IGF1, showing that IGF1 binding to IGF1R breaks the autoinhibitory interactions between the L1 and FnIII-2 domains in the apo state 7

p = 0.050) than patients in the control group (Supplemental Table S-3b)