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For instance, a study on hepatocellular carcinoma demonstrated that an 8-oxoG modification at the third position of miR-122 promotes tumorigenesis, whereas further oxidation of the second nucleotide to yield 2,3o8G-miR-122 transforms it into a tumor-suppressive miRNA

115 Polymeric Micelles Polymeric micelles differ from polymeric nanoparticles in their formation through self-assembly of amphiphilic block copolymers, creating a hydrophobic core and hydrophilic shell

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The same study indicated that UGT1A7 is only present in the proximal tissues of the gastrointestinal tract (mainly the esophagus and stomach) (Ohno and Nakajin, 2009)

Off-target effects and toxicity to normal tissues remain major challenges for metabolic therapies

Hirai et al