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Key design elements: Population: 145 adults (18 years) with NF1 and at least one symptomatic, inoperable PN measurable by volumetric MRI, randomized 1:1 to selumetinib (n=71) or placebo (n=74) for 12 cycles Inoperability criteria: PN defined as inoperable due to encasement of or proximity to vital structures, invasiveness, or high vascularity Primary endpoint: Confirmed ORR by cycle 16, assessed by independent central review using Response Evaluation in Neurofibromatosis and Schwannomatosis (REiNS) criteria, where response is defined as 20% reduction in PN tumor volume Results from KOMETs primary analysis, presented at ASCO 2025 and published in The Lancet , demonstrated: ORR 20% (14/71, 95% CI: 11.230.9) in the selumetinib arm vs
Clinical and epidemiological studies have indicated a correlation between low Zn levels and diabetes [120, 121]
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doi: 10.1038/s42255-020-00280-9 150 PatsoukisNBardhanKChatterjeePSariDLiuBBellLNet al
Traditionally, HUA was considered to solely cause gout and gouty arthritis
If not, I will definitely call because right now, the pain is intense, and due to the lupus joint pains, I have a high tolerance for pain
