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PMID: 8473389

Atypical cobalamin deficiency: subtle biochemical evidence of deficiency is commonly demonstrable in patients without megaloblastic anemia and is often associated with protein-bound cobalamin malabsorption

To overcome existing performance bottlenecks, future research should focus on the following aspects: (I) Organic matrices: There is a need to screen or develop carefully designed matrices to enhance their ionization and detection capabilities, thereby improving the authenticity, reproducibility, and quantitative accuracy of data, and enabling the accurate determination of various important endogenous and exogenous compounds and their metabolites