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Haeggstroem, J.Z

ROS may also mediate metabolism reprogramming ( Classical strategies include direct/indirect HIF targeting and interference in upstream/downstream HIF regulators/signaling pathways

The APE1 inefficiently cleaves but recruits various transcription factors to activate downstream genes, such as vascular endothelial growth factor (VEGF) and endonuclease IIIlike protein 1 (NTHL1) [95]

Given the absence of disease-modifying therapies that meaningfully slow disease progression, supportive care remains the mainstay of treatment for patients with ALS

This study introduces the term ferroptosis to describe a novel form of non-apoptotic cell death and identifies the small molecule ferrostatin 1 as the first specific inhibitor of ferroptosis

The participants were allocated to the two groups using blocked randomization and a computer-generated list of random numbers that had been prepared by an investigator with no involvement in this study