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4 Physiotherapy Programme, School of Rehabilitation Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia Background: Frailty is a biological syndrome of decreased reserve and resistance to stressors due to decline in multiple physiological systems

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Overall the analysis of hippocampus, inferior parietal lobule (IPL), and frontal cortex regions led to the identification of a similar set of oxidatively modified proteins (by PC, 3-NT, or HNE) in AD, EAD (a transitional stage between MCI and late-stage AD), and MCI subjects, proteins that play important roles in regulating energy metabolism (e.g., Eno 1, pyruvate kinase, ATP synthase), antioxidant and detoxification systems (e.g., peroxiredoxin, MnSOD), proteasomal activity (e.g., UCH-L1), cytoskeletal integrity (e.g., DRP-2, -tubulin), protein folding (e.g., HSP70), and cellular communication and signaling (e.g., neuropolypeptide h3) (18, 19, 28, 124, 199, 304309) (TABLE 4)

doi: 10.1124/jpet.108.137455

Regulation of fatty acid oxidation in rat brain mitochondria: inhibition of high rates of palmitate oxidation by ADP