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The GT1a was likely driven by PWID which increased dramatically in the late 1980s and 1990s up to 1% of the Portuguese population due to the rapid social and cultural changes that followed the revolution of 1974 and the increasing availability of heroin 69,70,71

Data availability Research data are stored in an institutional repository and can be shared upon request to the corresponding author

elegans 5 has emerged as a highly effective system for whole-organism high-throughput genetic 6,7,8,9,10,11,12,13,14 and drug 15,16,17,18,19 screening

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Scientific studies suggest that CLA supplementation may help reduce body fat by influencing enzymes and metabolic pathways involved in fat storage and breakdown

and the 6 questions version (IIEF-6) addressing exclusively penile erectile function, but considering the whole spectrum of erection related aspects, including erection frequency, erection firmness, penetration ability, erection maintenance frequency, erection maintenance ability, and erection confidence [30, 31]