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More research is needed to unravel the intricacies of its mechanisms and explore its therapeutic potential in the prevention of apoptosis-related conditions, especially in the male reproductive system

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Abnormal mitochondrial ferroptosis is observed in the hearts of diabetic mice, mainly manifested by decreased mitochondrial membrane potential, downregulated expression of key enzymes involved in antioxidant defence (superoxide dismutase [SOD 2 ] and glutathione peroxidase 1 [GPX 1 ]) in the mitochondria, and significantly increased mitochondrial ROS levels (57)

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Additionally, pulmonary delivery of AVPs may also be a preferred route of administration to target the localization of SARS-CoV-2 in the lungs, attributing to the large surface area and thin membrane barriers of the alveoli, which provided faster drug carrier absorption into the blood circulation [61]