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Many claims about their benefits may be influenced by the placebo effect, emphasizing the need for further research to validate these claims

IMPLICATIONS FOR GH REPLACEMENT Regardless of the exact mechanisms, the insulin antagonistic effects may cause concern when replacing adult GH deficient patients with GH, since some of these patients are insulin resistant in the untreated state

Due to their unique properties, such as high surface-to-mass ratio, stability, and ability to interact with both hydrophilic and hydrophobic environments, NPs show great promise in treating NDs, as their ability to mimic cell membrane structures and encapsulate diverse pharmaceuticals, along with their potential for functionalization, enhances their usefulness in drug delivery and bio-sensing (22)

Swertiamarin and ( R )-gentiandiol reversed high-fat diet-induced metabolic disturbances, reduced serum alanine aminotransferase, aspartate aminotransferase, total cholesterol, triglyceride, low-density lipoprotein cholesterol and malondialdehyde, while elevated high-density lipoprotein cholesterol, superoxide dismutase and glutathione peroxidase

Intern Med J

In addition to durability, NA provides rapid, NIR-triggered on-demand cisplatin release (70% in 5 min) and prevents premature leakage, offering spatial and temporal control