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Generally, up to 1000 mcg a day of an oral tablet to treat a deficiency is considered safe

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[20] The disease is classified by the extent of involvement, depending on how far the disease extends: [14] proctitis (rectal inflammation), left-sided colitis (inflammation extending to the descending colon), and extensive colitis (inflammation proximal to the descending colon)
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doi: 10.4149/BLL_2017_081

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