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Upregulation of p53 expression in patients with colorectal cancer by administration of curcumin

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In some embodiments, an otic composition or formulation disclosed herein comprises less than about 10 ppm of water

Specifically, the Akt signal pathway directly acts on FoxO3a to reduce its expression, further inhibiting production of autophagy marker LC3B on the collagen matrix, leading to excessive collagen accumulation (Im et al., 2015)

Ethics statement The studies involving human participants were reviewed and approved by Affiliated Reproductive Hospital of Shandong University