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In one study of infertile women, the incidence distribution was surprisingly robust for minimal-to-mild cases at 68%, whereas women with moderate-to-severe disease constituted the remaining 32% (24)

Gastrointestinal Protection Supported by Preclinical Evidence For gastrointestinal disorders, the evidence is limited to studies demonstrating gastric mucosal protection, indicating potential benefit specifically in models of gastric irritation

The ATF4-mediated upregulation of amino acid transporters and one-carbon metabolism, including SLC1A1, SLC7A8 , and SHMT2 , presumably increases the supply of glutamate, cysteine, and glycine, which might act in concert for the biosynthesis of GSH

doi: 10.1167/IOVS.18-24882 [DOI] [PMC free article] [PubMed] [Google Scholar] 122.Curcio CA, Medeiros NE, Millican CL

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IPBES, 2019