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In particular, the Nrf2-Keap1-ARE pathway plays a central role in the regulation of antioxidant enzyme genes and cytoprotective defense (Lu et al., 2016

Resveratrol was detected to increase hippocampal ATP levels, mitochondrial DNA, the expressions of SIRT1 and peroxisome proliferator-activated receptor coactivator (PGC)1 as well as decrease Na + -K + -ATPase and pyruvate levels

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