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When that one comes in, he says of the forthcoming paper, Im going to drop the mike. If Sinclairs public comments push past the limits of what most scientists would say, it is also true that his accomplishments in the lab continue to push the limits of science itself

For instance, cholesterol synthesis is not only directly downregulated by statin via the mevalonate pathway, but also modulated by SREBP1 and PPAR which are also suppressed by statin, in addition, NF-kB-induced inflammation can be ameliorated by direct effects of statin, as well indirect effects due to reduced cholesterol synthesis

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10.1074/jbc.272.2.782 [DOI] [PubMed] [Google Scholar] Blake A