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IL-4 induce MCP-1 gene expression by dramatically increasing the transcription factor, signal transducers and activators of transcription 1 (STAT1 ) DNA binding activity, an effect that was attenuated by PDTC

In this study, we demonstrated that Np63 regulates GSH, which scavenges ROS and is generated from serine and glycine, in a NRF2-dependent manner

37 In this work, we further demonstrated that in GSH-depleted cells, TMZ induces a higher amount of DNA damage

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On the other hand, the antipyretic effects are believed to be produced from the inhibition of the hypothalamic heat regulating center