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Y-27,632 is a competitive inhibitor of both Rho-associated protein kinase ROCK1 and ROCK2 (serine-threonine kinases) that competes with ATP in binding the catalytic binding sites of these kinases and thereby interferes with membrane protrusion and vesicle shedding through suppressed activity on LIM kinase and myosin light chain (MLC) 9

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In many cases, oral antibiotic combinations can be a reasonable starting point, especially when treatment also addresses co-infections such as Babesia or Bartonella, inflammation, and symptom-specific complications

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J Clin Invest 117(9):25922601

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[DOI] [PubMed] [Google Scholar] 104.Lewis S.A., Berg J.R., Kleine T.J

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