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Sotetsuflavone ameliorates Crohn's disease-like colitis by inhibiting M1 macrophage-induced intestinal barrier damage via JNK and MAPK signalling

Branched-chain amino acid metabolism Branched-chain amino acids (BCAAs), comprising leucine, isoleucine and valine, undergo catabolism to yield acetyl-CoA and succinyl-CoA, thereby entering the TCA cycle and contributing to ATP synthesis 57

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Heme synthetic module Depending on the species, there are three synthetic pathways from urogen III to heme, including protoporphyrin-dependent (PPD), coproporphyrin-dependent (CPD), and siroheme-dependent (SHD) pathways (Fig

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