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One of its most significant effects on the skin occurs through its interaction with the enzyme tyrosinase

This remains an area of active investigation rather than settled science

The histone methyltransferase EZH2 is strongly induced in chronic inflammation of RA FLS, which may suppress CDKN2A expression and thus contribute to the abnormal response to FLS (88)

Chagri, S., Ng, D

Direct force can damage peptide structure and cause foaming

[5] This outperformance of two established dermatological actives is notable, though the study methodology, blinding procedures, and outcome measurement techniques are not described in the level of detail that independent peer review would demand