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[DOI] [PubMed] [Google Scholar] 62.Hiatt W.R., Regensteiner J.G., Wolfel E.E., Ruff L., Brass E.P

J Physiol 589.4 pp 963-973

-ketoisocaproate-induced hypersecretion of insulin by islets from diabetes-susceptible mice

nonostante ci, si osservato che queste due forme esterificate possiedono un'affinit differente per i tessuti dell'organismo

Wild-type IDH1 overexpression fully rescued the phenotype, demonstrating that the observations are not due to off-target effects (Extended Data Fig

Rodent models, however, permit controlled investigation of cellular and molecular mechanisms using transgenic manipulations that mimic human disease