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In this pathology astrocytes undergo mild reactive changes and often develop astro-tauopathy (see below)

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These changes affected the metagenome function related to brain function and inflammation

The NLRP3 inflammasome and its components, including NLRP3, pro-caspase-1, and the adaptor protein ASC, trigger the release of pro-inflammatory cytokines such as interleukin (IL)1, and lead to gasdermin D-mediated pyroptotic cell death 29 , likely contributing to the chronic inflammation and subsequent neurodegeneration that characterize AD

Treatment of rats during pubertal development with 2,3,7,8-tetrachlorodibenzo-p-dioxin alters both signaling kinase activities and epidermal growth factor receptor binding in the testis and the motility and acrosomal reaction of sperm