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In this aspect, astrocytic terminal processes, known as endfeet, contact the brain vasculature and enwrap the neuronal synapses, enabling the modulation of both neuronal activity and cerebral blood flow, following an elevation in intracellular Ca 2+ levels in the endfeets [24,29]

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Vital signs are taken before infusions

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2-Methoxyestradiol induces vasodilation by stimulating NO release via PPAR/PI3K/Akt pathway

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The immunosuppressive phenotype of tumor-associated LECs is also defined by the expression of PD-L1, a checkpoint inhibitor that interacts with its receptor PD-1 on T cells to induce peripheral T cell tolerance

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