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Many studies show that a key mechanism by which AngII influences autonomic dysfunction is via its ability to produce ROS

The transcriptional levels of five key genes ( hmgR, ipi, carG, carRA, carB ) and SR5AL obtained by qRT-PCR were normalized to that of the tef1 gene

suggests that the perioperative administration of an appropriate dose of dexmedetomidine can reduce the release of inflammatory mediators and neuroendocrine hormones, maintain cerebral homeostasis, and alleviate ischemic brain injury, thereby exerting a protective effect on the brain [44]

& Weiner, H

doi: 10.3390/biom12111640 125

discovered that Apoptosis-Inducing Factor Mitochondria-Associated 2(AIFM2) can reduce cellular sensitivity to iron-dependent cell death by decreasing Coenzyme Q10 (CoQ10) level, thereby exhibiting an anti-ferroptotic effect independent of GPX4 ( 3.4 Ferroptosis inhibitors 1(Fer-1) Fer-1 is a ferroptosis inhibitor obtained through high-throughput screening