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The histone deubiquitinating enzyme breast cancer 1(BRCA1)-associated protein 1 (BAP1) also inhibits SLC7A11 by reducing H2A ubiquitination (H2Aub) on the SLC7A11 promoter (Zhang et al., 2019)

doi: 10.1371/journal.pone.0234121

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3.6 Others pathomechanisms Estrogen can be an important contributing factor in melasma development and its effects are mostly seen in post-puberty and pregnant women, and also in women using oral contraceptives

Ganitumab reduces IGF-1R activation by binding the L2 domain, a section of the extracellular leucine-rich domain that contributes to ligand binding, thereby preventing both IGF-1 and IGF-2 interaction with the receptor [105]