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10.1038/s41556-022-00949-1 13 ClaraA.MartaK.PaulaM.-S.Lpez-PoloV.TorresT.PuigS.et al (2024)

Elevated ROS levels disrupt antioxidant defenses, including glutathione peroxidase 4 (GPX4) activity and the cystine/glutamate antiporter system (xCT), thereby disturbing redox homeostasis and promoting lipid peroxidation and ferroptosis-related cellular damage

These changes shift microbial metabolism toward greater short-chain fatty acid (SCFA) production, particularly butyrate, which supports epithelial energy metabolism, reinforces barrier function, and epigenetically regulates T-cell differentiation (Van Deuren et al., 2022)

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Sample heterogeneity and lack of reproducibility intra- and inter-laboratory

It provides advanced threat detection and adaptive authentication by analyzing user behavior in real-time to identify and neutralize potential threats