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Head-to-head comparisons between arginate and acetate forms in controlled human studies would quantify the bioavailability advantage in clinical terms
We evaluated this in the context of non-small cell lung cancer (NSCLC), given its sensitivity to cysteine starvation 24 and the robust mitochondrial metabolism exhibited by human lung tumors 25,26
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In summary, tubulin binders are the most widely used payloads among ADCs, being selected for 8 out of 15 marketed ADCs (53.3%) and 11 out of 24 ADCs in phase III clinical trials (45.8%)
10.1016/j.chemosphere.2018.11.028 130 ZhouY.ZhuQ.MaW.XiaB.XiaoX.ZhaoY.et al (2019b)
