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According to the 2021 edition of the WHO Classification of tumors of the CNS, gliomas are classified as grades 1 to 4 [2, 3]

Madsen KG, Skonberg C, Jurva U, Cornett C, Hansen SH, Johansen TN, et al

Enhancer remodeling regulates epigenetic adaptation and resistance to MEK1/2 inhibition in triple-negative breast cancer
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However, several limitations persist in current research
